** [http://colloquy.info/ Colloquy] A native Aqua IRC client that integrates well into OS X and offers a rich featureset.
**[http://homepage.mac.com/philrobin/conversation/ Conversation]
**[http://www.adiumx.com/ Adium] Mac port of Gaim (see below).
*Cross-platform
**[http://www.hacksrus.com/~ginda/chatzilla/ ChatZilla] an IRC extension for Firefox.